Eleganolone, a Diterpene from the French Marine Alga Bifurcaria bifurcata Inhibits Growth of the Human Pathogens Trypanosoma brucei and Plasmodium falciparum

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Abstract: 

Organic extracts of 20 species of French seaweed have been screened againstTrypanosoma brucei rhodesiensetrypomastigotes, the parasite responsible for sleepingsickness. These extracts have previously shown potent antiprotozoal activitiesin vitroagainstPlasmodium falciparumandLeishmania donovani. The selectivity of the extractswas also evaluated by testing cytotoxicity on a mammalian L6 cell line. The ethylacetateextract of the brown seaweed,Bifurcaria bifurcata,showed strong trypanocidal activitywith a mild selectivity index (IC50= 0.53 μg/mL;selectivity index (SI)= 11.6). Bio-guidedfractionation led to the isolation of eleganolone, the main diterpenoid isolated from thisspecies. Eleganolone contributes only mildly to the trypanocidal activity of the ethylacetate extract (IC50= 45.0 μM, SI = 4.0). However,a selective activity againstP. falciparumerythrocytic stagesin vitrohas been highlighted (IC50= 7.9 μM, SI = 21.6).

Author(s): 
Catherine Vonthron-Sénéchea
Annelise Lobstein
Anne-Marie Rusig
Marcel Kaiser
Barthélémy Attioua
Jean-Baptiste Gallé
Keywords: 
eleganolone
linear diterpene
Bifurcaria
Plasmodium falciparum
Trypanosoma
Link / Ref: 
Semantics Scholar
Attachment: 
PDF icon Eleganolone, a Diterpene from the French Marine Alga Bifurcaria bifurcata Inhibits Growth of the Human Pathogens Trypanosoma brucei and Plasmodium falciparum.pdf
Article Source: 
Mar. Drugs 2013 , 11 , 599 - 610
Category: 
Seaweed composition
Uses of Seaweeds: Miscellaneous