Antiangiogenic and antitumoral properties of a polysaccharide isolated from the seaweed Sargassum stenophyllum

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Abstract: 

The potential antiangiogenic and antitumoral properties of SargA, a polysaccharide extracted from the brown marine alga Sargassum stenophyllum, were studied in assays carried out in chick embryos and mice. Gelfoam plugs containing SargA (2–1500 lg/ plug) implanted in vivo into fertilized 6-day-old chicken eggs induced dose-related antiangiogenic activity in the chorioallantoic membrane (CAM). By day 8, the highest dose of SargA alone decreased the vessel number in the CAM by 64%, but coadminis

Author(s): 
Paulo Fernando Dias
Jarbas Mota Siqueira Jr Luiz Felipe Vendruscolo
Teresinha de Jesus Neiva Antonio Ricardo Gagliardi
Marcelo Maraschin Rosa Maria Ribeiro-do-Valle
Keywords: 
Polysaccharide
Angiogenesis
Antitumoral activity
Sargassum stenophyllum
Angiostatic activity
Link / Ref: 
Pubmed
Attachment: 
PDF icon Antiangiogenic and antitumoral properties of a polysaccharide isolated from the seaweed Sargassum stenophyllum.pdf
Article Source: 
Cancer Chemother Pharmacol (2005) 56: 436–446
Category: 
Basic Biology
Seaweed composition